In the realm of neuroscience, the exploration of neural circuit dynamics has led to significant breakthroughs in diagnosing and treating neurological disorders. A recent research project led by Jingyan Dong and his collaborative team focuses on developing a flexible neural probe with multi-modal sensing and modulation functions compatible with functional Magnetic Resonance Imaging (fMRI). This innovative approach could revolutionize fundamental brain research and the treatment of neurological disorders.
The challenge of multi-modal integration
Neural probes have proven effective in understanding the complex connections and functions of neuron circuits. To advance our understanding further and improve closed-loop neuromodulation, the research team recognized the need to integrate various techniques, such as functional Magnetic Resonance Imaging (fMRI), electrophysiology, optical sensing and stimulation, and neurochemistry. However, accommodating all these multi-modal functions within a single, fMRI-compatible probe posed a significant challenge.
Jingyan Dong emphasizes the importance of this challenge, stating, “Accommodating all these functions in a single probe is critically important but challenging.” The team’s proposed solution involves the development of a flexible neural probe with multi-modal functions, paving the way for transformative applications in both fundamental brain research and neurological disorders treatment.
Revolutionizing neural probe technology
The proposed neural probe is designed to be flexible and equipped with multiple functionalities, including organic electrolyte-gated transistors (OEGTs) for neural potential recording, polymer waveguide-enabled optogenetics and photodiode-based photometry, and organic electrochemical transistors (OECTs) for neurochemical sensing. Unlike traditional electrode-based neural probes, this innovative approach utilizes organic semiconductor (OSC) based sensors, significantly enhancing the sensitivity and selectivity of neural sensing and modulation techniques.
Jingyan Dong highlights the potential impact of this novel technology, stating, “This research will provide a transformative framework for the development of novel fMRI-compatible multi-modal neural probes.” The goal is to create a tool that not only deepens our understanding of neural circuits but also offers personalized treatments for neurological disorders, thus addressing a critical gap in current medical technology.
Collaboration and education
The research project extends beyond the confines of a single institution, with collaboration between North Carolina State University (NCSU), the University of North Carolina at Chapel Hill (UNC Chapel Hill), and the University of Missouri. This collaboration reflects a broader effort to link research outcomes with the development of the future workforce in biosensors, neural probe fabrication, and medical instrumentation.
According to Jingyan Dong, “By integrating research and education, this project will satisfy the needs of the modern industry for biosensors, neural probe fabrication, and medical instrumentation.” This holistic approach not only enhances the impact of the research on society but also contributes to the training of professionals who will drive future advancements in the field.
Impacts on society and benefits to mankind
The project aims to provide advanced tools for personalized neurological research and treatments. Neural probe sensing and modulation have already demonstrated their effectiveness in diagnosing and treating neurological disorders. However, the limitations of current neural probe systems in terms of functionalities and customizability hinder their broader applications.
The proposed flexible neural probe with multi-modal functions has the potential to overcome these limitations, revolutionizing applications in fundamental brain research and neurological disorder treatments. The impact on society is substantial, offering a deeper understanding of neural circuit dynamics and the promise of more personalized and effective treatments for individuals grappling with neurological disorders.
Jingyan Dong and his collaborative team’s research project represent a significant step forward in neuroscience and medical technology. The development of a flexible neural probe with multi-modal functions compatible with fMRI holds immense promise for advancing our understanding of the brain and improving treatments for neurological disorders. Through collaboration and education, this project contributes to scientific knowledge and prepares the next generation of professionals to drive innovation in the rapidly evolving field of neurotechnology.
This post was originally published in the Department of Industrial and Systems Engineering.
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